BEGIN:VCALENDAR
PRODID:-//Microsoft Corporation//Outlook MIMEDIR//EN
VERSION:2.0
BEGIN:VEVENT
DTSTART:20151117T223000Z
DTEND:20151117T230000Z
LOCATION:18AB
DESCRIPTION;ENCODING=QUOTED-PRINTABLE:ABSTRACT: Engineered proteins are synthetic novel proteins (not found in nature) that are designed to fulfill a predetermined biological function. Such proteins can be used as molecular markers,  inhibitory agents, or drugs. For example, a synthetic protein could bind to a critical protein of a pathogen, thereby inhibiting the function of the target protein and potentially reducing the impact of the pathogen. In this paper we present the In-Silico Protein Synthesizer (InSiPS), a massively parallel computational tool for the IBM Blue Gene/Q that is aimed at designing inhibitory proteins. More precisely, InSiPS designs proteins that are predicted to interact with a given target protein (and may inhibit the target's cellular functions) while leaving non-target proteins unaffected (to minimize side-effects). As proof-of-concepts, two InSiPS designed proteins have been synthesized in the lab and their inhibitory properties have been experimentally verified through wet-lab experimentation.
SUMMARY:Engineering Inhibitory Proteins with InSiPS: The In-Silico Protein Synthesizer
PRIORITY:3
END:VEVENT
END:VCALENDAR