SCHEDULE: NOV 15-20, 2015

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Engineering Inhibitory Proteins with InSiPS: The In-Silico Protein Synthesizer

SESSION: Applications: Folding, Imaging, and Proteins

EVENT TYPE: Papers

EVENT TAG(S): Applications

TIME: 4:30PM - 5:00PM

SESSION CHAIR(S): Evelyn Duesterwald

AUTHOR(S):Andrew Schoenrock, Daniel Burnside, Houman Moteshareie, Alex Wong, Ashkan Golshani, Frank Dehne, James R. Green

ROOM:18AB

ABSTRACT:

Engineered proteins are synthetic novel proteins (not found in nature) that are designed to fulfill a predetermined biological function. Such proteins can be used as molecular markers, inhibitory agents, or drugs. For example, a synthetic protein could bind to a critical protein of a pathogen, thereby inhibiting the function of the target protein and potentially reducing the impact of the pathogen. In this paper we present the In-Silico Protein Synthesizer (InSiPS), a massively parallel computational tool for the IBM Blue Gene/Q that is aimed at designing inhibitory proteins. More precisely, InSiPS designs proteins that are predicted to interact with a given target protein (and may inhibit the target's cellular functions) while leaving non-target proteins unaffected (to minimize side-effects). As proof-of-concepts, two InSiPS designed proteins have been synthesized in the lab and their inhibitory properties have been experimentally verified through wet-lab experimentation.

Chair/Author Details:

Evelyn Duesterwald (Chair) - IBM Corporation|

Andrew Schoenrock - Carleton University

Daniel Burnside - Carleton University

Houman Moteshareie - Carleton University

Alex Wong - Carleton University

Ashkan Golshani - Carleton University

Frank Dehne - Carleton University

James R. Green - Carleton University

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Paper provided by the ACM Digital Library

Paper also available from IEEE Computer Society